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Gene Information
Gene ID:170944
Full Name:dyskeratosis congenita 1, dyskerin
Organism:Rattus norvegicus (Rat)
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.4223
Original ID2:Dkc1
Fold Change:1.37
P Value:0.00999
Note:Lower levels in the hippocampus of iP than iNP rats
Dataset Information
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005732small nucleolar ribonucleoprotein complexCellular ComponentIDA (10679015)
GO:0015030Cajal bodyCellular ComponentIDA (7798307)
GO:0005634nucleusCellular ComponentIEA
GO:0005654nucleoplasmCellular ComponentIDA (7798307)
GO:0005730nucleolusCellular ComponentIDA (7798307)
GO:0030529ribonucleoprotein complexCellular ComponentIEA
GO:0016853isomerase activityMolecular FunctionIEA
GO:0003723RNA bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIDA (7798307)
GO:0016439tRNA-pseudouridine synthase activityMolecular FunctionIEA
GO:0008283cell proliferationBiological ProcessIDA (10679015)
GO:0006364rRNA processingBiological ProcessIEA
GO:0031119tRNA pseudouridine synthesisBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:170944