| Gene Information |
| Gene ID: | | 170944 |
| Symbol: | | Dkc1 |
| Full Name: | | dyskeratosis congenita 1, dyskerin |
| Alias: | | Nap57 |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | X |
| Gene Type: | | protein-coding |
| Human Ortholog: | | This gene has no human ortholog. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Rn.4223 | | Original ID2: | | Dkc1 | | Fold Change: | | 1.37 | | P Value: | | 0.00999 | | Note: | | Lower levels in the hippocampus of iP than iNP rats |
| | Dataset Information | | Name: | | 15660665 | | Method: | | Microarray | | Tissue: | | Hippocampus | | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | | Publication: | | Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed | | Summary: | | The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01). |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005732 | small nucleolar ribonucleoprotein complex | Cellular Component | IDA (10679015) | |
| GO:0015030 | Cajal body | Cellular Component | IDA (7798307) | |
| GO:0005634 | nucleus | Cellular Component | IEA | |
| GO:0005654 | nucleoplasm | Cellular Component | IDA (7798307) | |
| GO:0005730 | nucleolus | Cellular Component | IDA (7798307) | |
| GO:0030529 | ribonucleoprotein complex | Cellular Component | IEA | |
| GO:0016853 | isomerase activity | Molecular Function | IEA | |
| GO:0003723 | RNA binding | Molecular Function | IEA | |
| GO:0005515 | protein binding | Molecular Function | IDA (7798307) | |
| GO:0016439 | tRNA-pseudouridine synthase activity | Molecular Function | IEA | |
| GO:0008283 | cell proliferation | Biological Process | IDA (10679015) | |
| GO:0006364 | rRNA processing | Biological Process | IEA | |
| GO:0031119 | tRNA pseudouridine synthesis | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 170944 |
| RGD: | | 621780 |
| Ensembl: | | |
| dbSNP: | | Dkc1 |
