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Gene Information
Gene ID:171093
Symbol:Shank2
Full Name:SH3/ankyrin domain gene 2
Alias:CortBP1|ProSAP1|Spank-3
Organism:Rattus norvegicus (Rat)
Chromosome:1
Genetic Location:1q41
Physical Location:204399855-204855473 on NC_005100.2
Gene Type:protein-coding
Human Ortholog:GeneID: 22941    Symbol (Name): SHANK2 (SH3 and multiple ankyrin repeat domains 2)
Ortholog Status:The human GeneID 22941 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Shank2
Fold Change:1.17
P Value:0.004
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001004133.1NP_001004133.1NC_005100.2 range: 204399855..204855473
NM_133440.1NP_597684.1NC_005100.2 range: 204399855..204855473
NM_133441.1NP_597685.1NC_005100.2 range: 204399855..204855473
NM_201350.1NP_958738.1NC_005100.2 range: 204399855..204855473
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0014069postsynaptic densityCellular ComponentIDA (15014124|16439662)
GO:0045211postsynaptic membraneCellular ComponentIDA (10958799)
GO:0005515protein bindingMolecular FunctionIDA (10958799)
GO:0005515protein bindingMolecular FunctionISS
GO:0017124SH3 domain bindingMolecular FunctionIPI (15014124)
Other Database Cross Links
NCBI Entrez Gene:171093
RGD:628772
Ensembl:ENSRNOG00000029931
dbSNP:Shank2