ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mosc2

Full Name:

MOCO sulphurase C-terminal domain containing 2

Alias:

Mg87

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

13q26

Physical Location:

100809305-100838647 on NC_005112.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 54996 Symbol (Name): MOSC2 (MOCO sulphurase C-terminal domain containing 2)

Ortholog Status:

The human GeneID 54996 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.11802
Original ID2:		Mg87
Fold Change:		1.36
P Value:		0.00021
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_134410.1	NP_599237.1	NC_005112.2 range: 100809305..100838647, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0005741	mitochondrial outer membrane	Cellular Component	IEA
GO:0005743	mitochondrial inner membrane	Cellular Component	ISS
GO:0016020	membrane	Cellular Component	IEA
GO:0019867	outer membrane	Cellular Component	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0030151	molybdenum ion binding	Molecular Function	IEA
GO:0030170	pyridoxal phosphate binding	Molecular Function	IEA