ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mcm4

Full Name:

minichromosome maintenance deficient 4 homolog (S. cerevisiae)

Alias:

19G|AI325074|AU045576|Cdc21|KIAA4003|Mcmd4|mKIAA4003|mcdc21

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

16 B1|16 9.2 cM

Physical Location:

15624195-15637448 on NC_000082.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4173 Symbol (Name): MCM4 (minichromosome maintenance complex component 4)

Ortholog Status:

The human GeneID 4173 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		D26089
Note:		Differences expression between alcohol treatment and control groups

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008565.2	NP_032591.2	NC_000082.5 range: 15624195..15637448, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15917436)
GO:0003697	single-stranded DNA binding	Molecular Function	IPI (15917436)
GO:0003678	DNA helicase activity	Molecular Function	IPI (15917436)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0017111	nucleoside-triphosphatase activity	Molecular Function	IEA
GO:0006260	DNA replication	Biological Process	IEA
GO:0006268	DNA unwinding during replication	Biological Process	IPI (15917436)
GO:0006270	DNA replication initiation	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA