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Gene Information
Gene ID:17260
Symbol:Mef2c
Full Name:myocyte enhancer factor 2C
Alias:5430401D19Rik|9930028G15Rik|AV011172
Organism:Mus musculus (Mouse)
Chromosome:13
Genetic Location:13 C3|13 45.0 cM
Physical Location:83643193-83802947 on NC_000079.5
Gene Type:protein-coding
Human Ortholog:GeneID: 4208    Symbol (Name): MEF2C (myocyte enhancer factor 2C)
Ortholog Status:The human GeneID 4208 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Mef2c
Original ID2:AI595996
Gene Information
Original ID1:Mef2c
Original ID2:L13171
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_025282.2NP_079558.1NC_000079.5 range: 83643193..83802947
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIC (12130539)
GO:0005515protein bindingMolecular FunctionIPI (15102471)
GO:0003713transcription coactivator activityMolecular FunctionRCA (12466851)
GO:0003702RNA polymerase II transcription factor activityMolecular FunctionRCA (12466851)
GO:0003700transcription factor activityMolecular FunctionRCA (12466851)
GO:0003700transcription factor activityMolecular FunctionIDA (12130539)
GO:0003677DNA bindingMolecular FunctionIDA (14762206|16140986)
GO:0016563transcription activator activityMolecular FunctionIDA (9738004)
GO:0043565sequence-specific DNA bindingMolecular FunctionIDA (17336904)
GO:0007517muscle developmentBiological ProcessRCA (12466851)
GO:0045941positive regulation of transcriptionBiological ProcessIMP (9162005)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (17336904)
GO:0007507heart developmentBiological ProcessIMP (10395786)
GO:0007399nervous system developmentBiological ProcessRCA (12466851)
GO:0006366transcription from RNA polymerase II promoterBiological ProcessRCA (12466851)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIDA (9738004|12130539)
GO:0006350transcriptionBiological ProcessIEA
GO:0001568blood vessel developmentBiological ProcessIMP (17336904)
GO:0002062chondrocyte differentiationBiological ProcessIGI (17336904)
GO:0001974blood vessel remodelingBiological ProcessIMP (9162005|10395786)
GO:0001958endochondral ossificationBiological ProcessIMP (17336904)
GO:0001958endochondral ossificationBiological ProcessIGI (17336904)
GO:0001649osteoblast differentiationBiological ProcessIGI (17336904)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIGI (17336904)
Other Database Cross Links
NCBI Entrez Gene:17260
MGI:
Ensembl:ENSMUSG00000005583
dbSNP:Mef2c
AceView:Mef2c