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Gene Information
Gene ID:17350
Symbol:Mlh1
Full Name:mutL homolog 1 (E. coli)
Alias:1110035C23Rik|AI317206|AI325952|AI561766
Organism:Mus musculus (Mouse)
Chromosome:9
Genetic Location:9 F3|9 62.0 cM
Physical Location:111130758-111174065 on NC_000075.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 4292    Symbol (Name): MLH1 (mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli))
Ortholog Status:The human GeneID 4292 is also in human dataset(s).
Gene in Ethanol Study Datasets
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Etact2Alcohol Stimulated Activity96151-71 (cM)3.64.30E-05SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_026810.1NP_081086.1NC_000075.5 range: 111130758..111174065, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0032389MutLalpha complexCellular ComponentIDA (16713580)
GO:0000793condensed chromosomeCellular ComponentIDA (12091911|12913077)
GO:0000793condensed chromosomeCellular ComponentIMP (8673133)
GO:0000795synaptonemal complexCellular ComponentIDA (15467367|16260499)
GO:0005694chromosomeCellular ComponentIDA (11934988)
GO:0005634nucleusCellular ComponentIEA
GO:0043566structure-specific DNA bindingMolecular FunctionIDA (14716311)
GO:0032137guanine/thymine mispair bindingMolecular FunctionIGI (16713580)
GO:0030983mismatched DNA bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0032137guanine/thymine mispair bindingMolecular FunctionISO
GO:0016447somatic recombination of immunoglobulin gene segmentsBiological ProcessIMP (11828012)
GO:0016446somatic hypermutation of immunoglobulin genesBiological ProcessIMP (10092760|10429667)
GO:0008630DNA damage response, signal transduction resulting in induction of apoptosisBiological ProcessIMP (14562041)
GO:0007283spermatogenesisBiological ProcessIMP (8674118|12217320)
GO:0043060meiotic metaphase I plate congressionBiological ProcessIMP (10385520)
GO:0000239pachyteneBiological ProcessIMP (8674118)
GO:0045132meiotic chromosome segregationBiological ProcessIMP (12217320)
GO:0045190isotype switchingBiological ProcessIMP (12743174)
GO:0045950negative regulation of mitotic recombinationBiological ProcessIMP (15480418)
GO:0048477oogenesisBiological ProcessIMP (8674118)
GO:0007140male meiosisBiological ProcessIMP (15467367)
GO:0007131meiotic recombinationBiological ProcessIMP (8673133|10385520|16307920)
GO:0000289nuclear-transcribed mRNA poly(A) tail shorteningBiological ProcessIMP (11337385)
GO:0000712resolution of meiotic joint molecules as recombinantsBiological ProcessIMP (10385520|12217320)
GO:0002204somatic recombination of immunoglobulin genes during immune responseBiological ProcessIGI (12743174)
GO:0006281DNA repairBiological ProcessIMP (13679151|15480418)
GO:0006298mismatch repairBiological ProcessIDA (10747038)
GO:0006298mismatch repairBiological ProcessIMP (8674118|9500552|9560238|10096563|10359802|10429667|10657972|10851078|11313994|16204034|16728433)
GO:0006298mismatch repairBiological ProcessISS (11555625)
GO:0006303double-strand break repair via nonhomologous end joiningBiological ProcessIMP (15084308)
GO:0006974response to DNA damage stimulusBiological ProcessIGI (9560238|10657972)
GO:0006974response to DNA damage stimulusBiological ProcessIMP (14562041|16204034)
GO:0007049cell cycleBiological ProcessIEA
GO:0007060male meiosis chromosome segregationBiological ProcessIMP (8796278)
GO:0007126meiosisBiological ProcessIDA (12091911)
GO:0007126meiosisBiological ProcessTAS (10809667)
GO:0051257spindle midzone assembly involved in meiosisBiological ProcessIMP (10385520)
Other Database Cross Links
NCBI Entrez Gene:17350
MGI:
Ensembl:ENSMUSG00000032498
dbSNP:Mlh1
AceView:Mlh1