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Gene Information
Gene ID:4292
Symbol:MLH1
Full Name:mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
Alias:COCA2|FCC2|HNPCC|HNPCC2|MGC5172|hMLH1
Organism:Homo sapiens (Human)
Chromosome:3
Genetic Location:3p21.3
Physical Location:37009982-37067340 on NC_000003.10
Gene Type:protein-coding
Orthologs:This gene has Mouse: 17350 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:MLH1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000249.2NP_000240.1NC_000003.10 range: 37009982..37067340
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIC (11809883)
GO:0005634nucleusCellular ComponentIEA
GO:0003697single-stranded DNA bindingMolecular FunctionIDA (11809883)
GO:0005515protein bindingMolecular FunctionIPI (2414623|11427529|11429708|14676842)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0032407MutSalpha complex bindingMolecular FunctionIDA (16403449)
GO:0032137guanine/thymine mispair bindingMolecular FunctionIMP (16713580)
GO:0030983mismatched DNA bindingMolecular FunctionIEA
GO:0006298mismatch repairBiological ProcessTAS (8128251)
GO:0006298mismatch repairBiological ProcessIMP (11555625)
GO:0006298mismatch repairBiological ProcessIEA
GO:0045786negative regulation of cell cycleBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:4292
HGNC:7127
Ensembl:ENSG00000076242
MIM:120436
HPRD:00390
HuGE Navigator:4292
dbSNP:MLH1
GeneCard:MLH1
AceView:MLH1