ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mobp

Full Name:

myelin-associated oligodendrocytic basic protein

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 F4|9 69.0 cM

Physical Location:

120058859-120085208 on NC_000075.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4336 Symbol (Name): MOBP (myelin-associated oligodendrocyte basic protein)

Ortholog Status:

The human GeneID 4336 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI836582
Fold Change:		1.6, 2.0, 2.0, 1.6
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Gene Information

Original ID1:		AI849019
Fold Change:		1.7, 1.9, NC, NC
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Information

Original ID1:		Mobp
Original ID2:		AI834776

Gene Information

Original ID1:		Mobp
Original ID2:		AI839662

Gene Information

Original ID1:		Mobp
Original ID2:		U81317

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Etact2	Alcohol Stimulated Activity	9	61	51-71 (cM)	3.6	4.30E-05	Significant	PARC

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IDA (15625715)
GO:0019911	structural constituent of myelin sheath	Molecular Function	IDA (10077700)