ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mt1

Full Name:

metallothionein 1

Alias:

MT-I|Mt-1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 C5|8 45.0 cM

Physical Location:

96703126-96704223 on NC_000074.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4489 Symbol (Name): MT1A (metallothionein 1A)

Ortholog Status:

The human GeneID 4489 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		V00835
Fold Change:		1.5, 1.5, 1.7, 1.7
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Information

Original ID1:		Mt1
Original ID2:		V00835

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013602.2	NP_038630.1	NC_000074.5 range: 96703126..96704223

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005764	lysosome	Cellular Component	IDA (9358851)
GO:0005829	cytosol	Cellular Component	IDA (9358851)
GO:0005507	copper ion binding	Molecular Function	IDA (9358851)
GO:0008270	zinc ion binding	Molecular Function	TAS (11792622)
GO:0046872	metal ion binding	Molecular Function	IDA (12130647\|15033980)
GO:0006875	cellular metal ion homeostasis	Biological Process	IDA (12130647\|15033980)
GO:0006882	cellular zinc ion homeostasis	Biological Process	IMP (11792622)
GO:0007263	nitric oxide mediated signal transduction	Biological Process	IMP (11792622)
GO:0010273	detoxification of copper ion	Biological Process	IGI (8640230)