ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mast2

Full Name:

microtubule associated serine/threonine kinase 2

Alias:

MAST205|Mtssk|mKIAA0807

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 C7

Physical Location:

115979366-116136787 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 23139 Symbol (Name): MAST2 (microtubule associated serine/threonine kinase 2)

Ortholog Status:

The human GeneID 23139 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Mast2
Original ID2:		U02313

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0015630	microtubule cytoskeleton	Cellular Component	IDA (8246979)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0008017	microtubule binding	Molecular Function	IDA (8246979)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IDA (8246979)
GO:0005515	protein binding	Molecular Function	IPI (10404183\|14764729\|15951562)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (8246979)
GO:0004672	protein kinase activity	Molecular Function	RCA (12466851)
GO:0000287	magnesium ion binding	Molecular Function	IDA (8246979)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0045075	regulation of interleukin-12 biosynthetic process	Biological Process	IDA (14764729)
GO:0007242	intracellular signaling cascade	Biological Process	RCA (12466851)
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (8246979)
GO:0048515	spermatid differentiation	Biological Process	IDA (8902215)