ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

17886

Symbol:

Myh9

Full Name:

myosin, heavy polypeptide 9, non-muscle

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 E1|15 43.3 cM

Physical Location:

77591018-77672544 on NC_000081.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4627 Symbol (Name): MYH9 (myosin, heavy chain 9, non-muscle)

Ortholog Status:

The human GeneID 4627 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Myh9
Original ID2:		AI505453

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore5	Alcohol-induced Loss of Righting Reflex	15		18.8-61.7 (cM)	4		Significant	PARC
Aaq1/Etacc	Alcohol Acceptance	15	30	15-48 (cM)	3.8		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022410.2	NP_071855.2	NC_000081.5 range: 77591018..77672544, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	IDA (12893741\|16895968)
GO:0005737	cytoplasm	Cellular Component	IDA (9725909\|15177565\|15292239\|15555549)
GO:0005886	plasma membrane	Cellular Component	ISO
GO:0005913	cell-cell adherens junction	Cellular Component	IDA (15292239)
GO:0005938	cell cortex	Cellular Component	IDA (9725909\|16895968)
GO:0016459	myosin complex	Cellular Component	IDA (8482409\|9356462\|9725909)
GO:0001931	uropod	Cellular Component	ISO
GO:0001931	uropod	Cellular Component	IDA (15064761)
GO:0001772	immunological synapse	Cellular Component	ISO
GO:0001772	immunological synapse	Cellular Component	IDA (15064761)
GO:0031594	neuromuscular junction	Cellular Component	IDA (16012337)
GO:0005819	spindle	Cellular Component	IDA (9725909)
GO:0001725	stress fiber	Cellular Component	IDA (16895968)
GO:0001725	stress fiber	Cellular Component	ISO
GO:0030863	cortical cytoskeleton	Cellular Component	IDA (12893741)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0043531	ADP binding	Molecular Function	ISO
GO:0051015	actin filament binding	Molecular Function	ISO
GO:0030898	actin-dependent ATPase activity	Molecular Function	ISO
GO:0000146	microfilament motor activity	Molecular Function	ISO
GO:0005524	ATP binding	Molecular Function	ISO
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003774	motor activity	Molecular Function	IEA
GO:0003779	actin binding	Molecular Function	ISO
GO:0005516	calmodulin binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (16407977)
GO:0007132	meiotic metaphase I	Biological Process	IDA (9725909)
GO:0000212	meiotic spindle organization and biogenesis	Biological Process	IDA (9725909)
GO:0032796	uropod organization and biogenesis	Biological Process	IMP (15064761)
GO:0000904	cellular morphogenesis during differentiation	Biological Process	IMP (15292239)
GO:0001701	in utero embryonic development	Biological Process	IMP (15555549\|16630581)
GO:0001768	establishment of T cell polarity	Biological Process	IMP (15064761)
GO:0030048	actin filament-based movement	Biological Process	ISO
GO:0006928	cell motility	Biological Process	IMP (15064761)
GO:0016337	cell-cell adhesion	Biological Process	IMP (15292239)
GO:0008360	regulation of cell shape	Biological Process	IMP (16895968)
GO:0007520	myoblast fusion	Biological Process	IMP (16895968)
GO:0007155	cell adhesion	Biological Process	IMP (16407977)
GO:0051295	establishment of meiotic spindle localization	Biological Process	IDA (9725909)