ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nedd4

Full Name:

neural precursor cell expressed, developmentally down-regulated gene 4

Alias:

AA959633|AL023035|AU019897|E430025J12Rik|Nedd4-1|Nedd4a|mKIAA0093

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 D|9 40.0 cM

Physical Location:

72510153-72597654 on NC_000075.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4734 Symbol (Name): NEDD4 (neural precursor cell expressed, developmentally down-regulated 4)

Ortholog Status:

The human GeneID 4734 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Nedd4
Original ID2:		AF026124

Gene Information

Original ID1:		---
Original ID2:		U96635

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010890.3	NP_035020.2	NC_000075.5 range: 72510153..72597654

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000151	ubiquitin ligase complex	Cellular Component	IPI (11042109)
GO:0005829	cytosol	Cellular Component	IDA (9182527)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (10446181)
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	TAS (11042109)
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IDA (9182527)
GO:0016874	ligase activity	Molecular Function	IEA
GO:0006464	protein modification process	Biological Process	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA