ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nfib

Full Name:

nuclear factor I/B

Alias:

6720429L07Rik|E030026I10Rik

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 C4-C6|4 38.6 cM

Physical Location:

81941634-82151026 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4781 Symbol (Name): NFIB (nuclear factor I/B)

Ortholog Status:

The human GeneID 4781 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Nfib
Original ID2:		Y07685

Gene Information

Original ID1:		Nfib
Original ID2:		Y07686

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008687.5	NP_032713.3	NC_000070.5 range: 81941634..82151026, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0030900	forebrain development	Biological Process	IMP (15632069)
GO:0030324	lung development	Biological Process	IMP (11850179\|15632069)
GO:0008285	negative regulation of cell proliferation	Biological Process	IMP (15632069)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006260	DNA replication	Biological Process	IEA
GO:0030902	hindbrain development	Biological Process	IMP (15632069)