ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nfkbia

Full Name:

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Alias:

AI462015|Nfkbi

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

12 C1-C3

Physical Location:

56590830-56593569 on NC_000078.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4792 Symbol (Name): NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha)

Ortholog Status:

The human GeneID 4792 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U57524
Fold Change:		1.7, 1.6, 2.3, 2.0
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Gene Information

Original ID1:		AI642048
Fold Change:		1.7, 1.7, 2.6, 2.5
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010907.1	NP_035037.1	NC_000078.5 range: 56590830..56593569, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (11799106)
GO:0005737	cytoplasm	Cellular Component	IDA (11799106)
GO:0005829	cytosol	Cellular Component	IDA (11799106)
GO:0005515	protein binding	Molecular Function	IPI (15102471\|16371367)
GO:0000060	protein import into nucleus, translocation	Biological Process	IDA (11799106)
GO:0045638	negative regulation of myeloid cell differentiation	Biological Process	IMP (15845452)
GO:0043330	response to exogenous dsRNA	Biological Process	IDA (12872135)
GO:0042127	regulation of cell proliferation	Biological Process	IDA (11799106)
GO:0032496	response to lipopolysaccharide	Biological Process	IDA (12872135)
GO:0032495	response to muramyl dipeptide	Biological Process	IDA (15692051)
GO:0031663	lipopolysaccharide-mediated signaling pathway	Biological Process	IDA (12872135)
GO:0045746	negative regulation of Notch signaling pathway	Biological Process	IMP (15845452)