ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NFKBIA

Full Name:

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Alias:

IKBA|MAD-3|NFKBI

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

14q13

Physical Location:

34940467-34943694 on NC_000014.7, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 18035 Rat: 25493 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D14S70

33528945

Region:		31528945-35528945
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_020529.2	NP_065390.1	NC_000014.7 range: 34940467..34943694, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (7679069)
GO:0005737	cytoplasm	Cellular Component	IDA (3140380)
GO:0005829	cytosol	Cellular Component	EXP (10723127)
GO:0042802	identical protein binding	Molecular Function	IPI (16951195)
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI (9859996)
GO:0008139	nuclear localization sequence binding	Molecular Function	IPI (1493333)
GO:0051059	NF-kappaB binding	Molecular Function	IPI (7739562)
GO:0007253	cytoplasmic sequestering of NF-kappaB	Biological Process	NAS
GO:0042345	regulation of NF-kappaB import into nucleus	Biological Process	NAS (3140380)
GO:0006915	apoptosis	Biological Process	TAS (10747850)
GO:0043392	negative regulation of DNA binding	Biological Process	NAS (3140380)