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Gene Information
Gene ID:4792
Symbol:NFKBIA
Full Name:nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Alias:IKBA|MAD-3|NFKBI
Organism:Homo sapiens (Human)
Chromosome:14
Genetic Location:14q13
Physical Location:34940467-34943694 on NC_000014.7, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 18035 Rat: 25493 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D14S70  33528945
Region:31528945-35528945
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_020529.2NP_065390.1NC_000014.7 range: 34940467..34943694, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (7679069)
GO:0005737cytoplasmCellular ComponentIDA (3140380)
GO:0005829cytosolCellular ComponentEXP (10723127)
GO:0042802identical protein bindingMolecular FunctionIPI (16951195)
GO:0031625ubiquitin protein ligase bindingMolecular FunctionIPI (9859996)
GO:0008139nuclear localization sequence bindingMolecular FunctionIPI (1493333)
GO:0051059NF-kappaB bindingMolecular FunctionIPI (7739562)
GO:0007253cytoplasmic sequestering of NF-kappaBBiological ProcessNAS
GO:0042345regulation of NF-kappaB import into nucleusBiological ProcessNAS (3140380)
GO:0006915apoptosisBiological ProcessTAS (10747850)
GO:0043392negative regulation of DNA bindingBiological ProcessNAS (3140380)
Other Database Cross Links
NCBI Entrez Gene:4792
HGNC:7797
Ensembl:ENSG00000100906
MIM:164008
HPRD:01235
HuGE Navigator:4792
dbSNP:NFKBIA
GeneCard:NFKBIA
AceView:NFKBIA