ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

25493

Symbol:

Nfkbia

Full Name:

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Alias:

RL/IF-1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

6q23

Physical Location:

75729301-75732441 on NC_005105.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4792 Symbol (Name): NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha)

Ortholog Status:

The human GeneID 4792 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Nfkbia
Fold Change:		1.19
P Value:		0.006
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Nfkbia
Fold Change:		1.23
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_343065.3	XP_343066.2	NC_005105.2 range: 75729301..75732441, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0043234	protein complex	Cellular Component	IDA (16135962)
GO:0005829	cytosol	Cellular Component	ISS
GO:0005829	cytosol	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	IDA (16135962)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IEA
GO:0031625	ubiquitin protein ligase binding	Molecular Function	ISS
GO:0051059	NF-kappaB binding	Molecular Function	IEA
GO:0042802	identical protein binding	Molecular Function	ISS
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IEA
GO:0031072	heat shock protein binding	Molecular Function	IPI (16135962)
GO:0008139	nuclear localization sequence binding	Molecular Function	ISS
GO:0051059	NF-kappaB binding	Molecular Function	IPI (16135962)
GO:0051059	NF-kappaB binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0008139	nuclear localization sequence binding	Molecular Function	IEA
GO:0045746	negative regulation of Notch signaling pathway	Biological Process	ISS
GO:0045746	negative regulation of Notch signaling pathway	Biological Process	IEA
GO:0045638	negative regulation of myeloid cell differentiation	Biological Process	IEA
GO:0043330	response to exogenous dsRNA	Biological Process	ISS
GO:0043330	response to exogenous dsRNA	Biological Process	IEA
GO:0045638	negative regulation of myeloid cell differentiation	Biological Process	ISS
GO:0042127	regulation of cell proliferation	Biological Process	ISS
GO:0042127	regulation of cell proliferation	Biological Process	IEA
GO:0032496	response to lipopolysaccharide	Biological Process	ISS
GO:0032496	response to lipopolysaccharide	Biological Process	IEA
GO:0032495	response to muramyl dipeptide	Biological Process	ISS
GO:0031663	lipopolysaccharide-mediated signaling pathway	Biological Process	ISS
GO:0031663	lipopolysaccharide-mediated signaling pathway	Biological Process	IEA
GO:0000060	protein import into nucleus, translocation	Biological Process	ISS
GO:0000060	protein import into nucleus, translocation	Biological Process	IEA