ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ngf

Full Name:

nerve growth factor

Alias:

Ngfb

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

3 F2.2|3 48.5 cM

Physical Location:

102273850-102324927 on NC_000069.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4803 Symbol (Name): NGF (nerve growth factor (beta polypeptide))

Ortholog Status:

The human GeneID 4803 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ngfb
Fold Change:		0.7
Note:		Significantly regulated by ethanol in cortical neurons

Gene Information

Original ID1:		Ngfb
Fold Change:		0.61
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013609.2	NP_038637.1	NC_000069.5 range: 102273850..102324927

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	EXP (11147812)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005788	endoplasmic reticulum lumen	Cellular Component	EXP (925010)
GO:0005057	receptor signaling protein activity	Molecular Function	IDA (12473665)
GO:0008083	growth factor activity	Molecular Function	IEA
GO:0045773	positive regulation of axon extension	Biological Process	IMP (8861722)
GO:0045664	regulation of neuron differentiation	Biological Process	IDA (16516892)
GO:0019233	sensory perception of pain	Biological Process	IMP (8137419)
GO:0007422	peripheral nervous system development	Biological Process	IMP (14736860)
GO:0046928	regulation of neurotransmitter secretion	Biological Process	IGI (16298082)