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Gene Information
Gene ID:18049
Full Name:nerve growth factor
Organism:Mus musculus (Mouse)
Genetic Location:3 F2.2|3 48.5 cM
Physical Location:102273850-102324927 on NC_000069.5
Gene Type:protein-coding
Human Ortholog:GeneID: 4803    Symbol (Name): NGF (nerve growth factor (beta polypeptide))
Ortholog Status:The human GeneID 4803 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ngfb
Fold Change:0.7
Note:Significantly regulated by ethanol in cortical neurons
Gene Information
Original ID1:Ngfb
Fold Change:0.61
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013609.2NP_038637.1NC_000069.5 range: 102273850..102324927
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentEXP (11147812)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0005788endoplasmic reticulum lumenCellular ComponentEXP (925010)
GO:0005057receptor signaling protein activityMolecular FunctionIDA (12473665)
GO:0008083growth factor activityMolecular FunctionIEA
GO:0045773positive regulation of axon extensionBiological ProcessIMP (8861722)
GO:0045664regulation of neuron differentiationBiological ProcessIDA (16516892)
GO:0019233sensory perception of painBiological ProcessIMP (8137419)
GO:0007422peripheral nervous system developmentBiological ProcessIMP (14736860)
GO:0046928regulation of neurotransmitter secretionBiological ProcessIGI (16298082)
Other Database Cross Links
NCBI Entrez Gene:18049