ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NGF

Full Name:

nerve growth factor (beta polypeptide)

Alias:

Beta-NGF|HSAN5|MGC161426|MGC161428|NGFB

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1p13.1

Physical Location:

115630059-115682379 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 18049 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

NGFB

Dataset Information

Name:		18477577
Method:		Addiction array gene list
Publication:		Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:		To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

Gene Information

Original ID1:

NGF

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002506.2	NP_002497.2	NC_000001.9 range: 115630059..115682379, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	EXP (11157096\|12787574\|16284401)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005768	endosome	Cellular Component	EXP (7806500\|9182757\|10629055\|16284401)
GO:0005796	Golgi lumen	Cellular Component	EXP (8615794\|12787574)
GO:0004871	signal transducer activity	Molecular Function	TAS (6688123)
GO:0005163	nerve growth factor receptor binding	Molecular Function	IPI (14985763)
GO:0008083	growth factor activity	Molecular Function	IEA
GO:0007275	multicellular organismal development	Biological Process	NR
GO:0007267	cell-cell signaling	Biological Process	NR
GO:0007265	Ras protein signal transduction	Biological Process	EXP (11520933)
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	EXP (16939974)
GO:0032455	nerve growth factor processing	Biological Process	EXP (12787574)