| Gene Information |
| Gene ID: | | 1846 |
| Symbol: | | DUSP4 |
| Full Name: | | dual specificity phosphatase 4 |
| Alias: | | HVH2|MKP-2|MKP2|TYP |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 8 |
| Genetic Location: | | 8p12-p11 |
| Physical Location: | | 29249529-29264103 on NC_000008.9, complement |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | DUSP4 | | Original ID2: | | U21108 |
| | Dataset Information | | Name: | | 11093800 | | Method: | | Microarray | | Tissue: | | SH-SY5Y neuroblastoma cells | | Phenotype: | | Ethanol response | | Publication: | | Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed | | Summary: | | We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005634 | nucleus | Cellular Component | TAS (7535768) | |
| GO:0005654 | nucleoplasm | Cellular Component | EXP (17322878) | |
| GO:0004725 | protein tyrosine phosphatase activity | Molecular Function | EXP (17322878) | |
| GO:0004725 | protein tyrosine phosphatase activity | Molecular Function | IEA | |
| GO:0008330 | protein tyrosine/threonine phosphatase activity | Molecular Function | TAS (7535768) | |
| GO:0016787 | hydrolase activity | Molecular Function | IEA | |
| GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity | Molecular Function | IEA | |
| GO:0000165 | MAPKKK cascade | Biological Process | TAS (7535768) | |
| GO:0006470 | protein amino acid dephosphorylation | Biological Process | TAS (7535768) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 1846 |
| HGNC: | | 3070 |
| Ensembl: | | ENSG00000120875 |
| MIM: | | 602747 |
| HPRD: | | 04123 |
| HuGE Navigator: | | 1846 |
| dbSNP: | | DUSP4 |
| GeneCard: | | DUSP4 |
| AceView: | | DUSP4 |
