ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pak3

Full Name:

p21 (CDKN1A)-activated kinase 3

Alias:

PAK-3|Pak65alpha|Pak65beta|Stk4|mPAK-3

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

X F2

Physical Location:

140127829-140226346 on NC_000086.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5063 Symbol (Name): PAK3 (p21 (CDKN1A)-activated kinase 3)

Ortholog Status:

The human GeneID 5063 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pak3
Original ID2:		U39738

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008778.2	NP_032804.2	NC_000086.6 range: 140127829..140226346

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (7493928\|9428767)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA