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Gene Information
Gene ID:18481
Symbol:Pak3
Full Name:p21 (CDKN1A)-activated kinase 3
Alias:PAK-3|Pak65alpha|Pak65beta|Stk4|mPAK-3
Organism:Mus musculus (Mouse)
Chromosome:X
Genetic Location:X F2
Physical Location:140127829-140226346 on NC_000086.6
Gene Type:protein-coding
Human Ortholog:GeneID: 5063    Symbol (Name): PAK3 (p21 (CDKN1A)-activated kinase 3)
Ortholog Status:The human GeneID 5063 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pak3
Original ID2:U39738
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_008778.2NP_032804.2NC_000086.6 range: 140127829..140226346
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0016301kinase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (7493928|9428767)
GO:0004674protein serine/threonine kinase activityMolecular FunctionIEA
GO:0004672protein kinase activityMolecular FunctionIEA
GO:0003824catalytic activityMolecular FunctionIEA
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0007275multicellular organismal developmentBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:18481
MGI:
Ensembl:ENSMUSG00000031284
dbSNP:Pak3
AceView:Pak3