ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pbx3

Full Name:

pre B-cell leukemia transcription factor 3

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 B|2 22.0 cM

Physical Location:

34027428-34227555 on NC_000068.6, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5090 Symbol (Name): PBX3 (pre-B-cell leukemia homeobox 3)

Ortholog Status:

The human GeneID 5090 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pbx3
Original ID2:		AF020200

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcp1	Alcohol Preference Drinking	2	28	19-35 (cM)	5.3		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016768.1	NP_058048.1	NC_000068.6 range: 34027428..34227555, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (15466398)
GO:0005667	transcription factor complex	Cellular Component	IDA (15466398)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15466398)
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (16847320)
GO:0007585	respiratory gaseous exchange	Biological Process	IMP (15466398)
GO:0007388	posterior compartment specification	Biological Process	RCA (12466851)
GO:0007387	anterior compartment specification	Biological Process	RCA (12466851)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0045449	regulation of transcription	Biological Process	IEA