ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pcaf

Full Name:

p300/CBP-associated factor

Alias:

A930006P13Rik|AI461839|AW536563

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

17 C|17 30.0 cM

Physical Location:

53706639-53812044 on NC_000083.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8850 Symbol (Name): PCAF (p300/CBP-associated factor)

Ortholog Status:

The human GeneID 8850 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pcaf
Original ID2:		AW047728

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_020005.3	NP_064389.2	NC_000083.5 range: 53706639..53812044

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000123	histone acetyltransferase complex	Cellular Component	IDA (9742083)
GO:0005634	nucleus	Cellular Component	IDA (15509593)
GO:0000776	kinetochore	Cellular Component	IDA (14519686)
GO:0003713	transcription coactivator activity	Molecular Function	IDA (15509593\|15647252)
GO:0008415	acyltransferase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (9742083\|15509593\|15647252)
GO:0004406	H3/H4 histone acetyltransferase activity	Molecular Function	IDA (15992539)
GO:0004402	histone acetyltransferase activity	Molecular Function	IDA (9742083)
GO:0008080	N-acetyltransferase activity	Molecular Function	RCA (12466851)
GO:0016573	histone acetylation	Biological Process	IDA (15992539)
GO:0008152	metabolic process	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0006473	protein amino acid acetylation	Biological Process	TAS (10722926)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	TAS (10722926)
GO:0006350	transcription	Biological Process	IEA
GO:0045941	positive regulation of transcription	Biological Process	IDA (15509593\|15647252)