ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

DUT

Full Name:

deoxyuridine triphosphatase

Alias:

FLJ20622|dUTPase

Organism:

Homo sapiens (Human)

Chromosome:

15

Genetic Location:

15q15-q21.1

Physical Location:

46410912-46422861 on NC_000015.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.527980
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001025248.1	NP_001020419.1	NC_000015.8 range: 46410912..46422861
NM_001025249.1	NP_001020420.1	NC_000015.8 range: 46410912..46422861
NM_001948.3	NP_001939.1	NC_000015.8 range: 46410912..46422861

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	EXP (8631816)
GO:0005634	nucleus	Cellular Component	TAS (8631816)
GO:0005739	mitochondrion	Cellular Component	TAS (8631816)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0004170	dUTP diphosphatase activity	Molecular Function	TAS (8631816)
GO:0004170	dUTP diphosphatase activity	Molecular Function	EXP (8631816)
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	Biological Process	TAS (1325640)
GO:0006260	DNA replication	Biological Process	TAS (1325640)
GO:0009117	nucleotide metabolic process	Biological Process	IEA
GO:0046080	dUTP metabolic process	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000128951

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: