ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pde1b

Full Name:

phosphodiesterase 1B, Ca2+-calmodulin dependent

Alias:

63kDa|Pde1b1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 F3

Physical Location:

103333729-103360482 on NC_000081.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5153 Symbol (Name): PDE1B (phosphodiesterase 1B, calmodulin-dependent)

Ortholog Status:

The human GeneID 5153 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pde1b
Original ID2:		AF023343

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008800.1	NP_032826.1	NC_000081.5 range: 103333729..103360482

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	Molecular Function	IEA
GO:0005516	calmodulin binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	IMP (12077213)
GO:0007626	locomotory behavior	Biological Process	IMP (12077213)
GO:0008542	visual learning	Biological Process	IMP (12077213)