ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pdgfa

Full Name:

platelet derived growth factor, alpha

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 G2|5 82.0 cM

Physical Location:

139452924-139470906 on NC_000071.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5154 Symbol (Name): PDGFA (platelet-derived growth factor alpha polypeptide)

Ortholog Status:

The human GeneID 5154 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pdgfa
Fold Change:		1.44
Note:		Significantly regulated by ethanol in cortical neurons

Gene Information

Original ID1:		Pdgfa
Fold Change:		1.56
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008808.3	NP_032834.1	NC_000071.5 range: 139452924..139470906, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005902	microvillus	Cellular Component	IDA (12101409)
GO:0016020	membrane	Cellular Component	IEA
GO:0008083	growth factor activity	Molecular Function	IEA
GO:0001525	angiogenesis	Biological Process	IDA (12101409)
GO:0048286	alveolus development	Biological Process	IMP (11803579)
GO:0030036	actin cytoskeleton organization and biogenesis	Biological Process	IDA (12176888)
GO:0030031	cell projection biogenesis	Biological Process	IDA (12176888)
GO:0009887	organ morphogenesis	Biological Process	IMP (14522834)
GO:0009887	organ morphogenesis	Biological Process	IGI (15361870)
GO:0008284	positive regulation of cell proliferation	Biological Process	ISO
GO:0008283	cell proliferation	Biological Process	IEA
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Biological Process	IDA (11940581)