ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

5154

Symbol:

PDGFA

Full Name:

platelet-derived growth factor alpha polypeptide

Alias:

PDGF-A|PDGF1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

7p22

Physical Location:

503420-526006 on NC_000007.12, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 18590 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

PDGFA

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002607.4	NP_002598.4	NC_000007.12 range: 503420..526006, complement
NM_033023.3	NP_148983.1	NC_000007.12 range: 503420..526006, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0009986	cell surface	Cellular Component	IDA (291037\|2836953)
GO:0005576	extracellular region	Cellular Component	EXP (287022)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IDA (3754619)
GO:0031089	platelet dense granule lumen	Cellular Component	EXP (287022)
GO:0043498	cell surface binding	Molecular Function	IDA (291037\|2538439\|2836953)
GO:0046982	protein heterodimerization activity	Molecular Function	IPI (7073684)
GO:0042803	protein homodimerization activity	Molecular Function	IDA (2836953\|3754619)
GO:0008083	growth factor activity	Molecular Function	IEA
GO:0048407	platelet-derived growth factor binding	Molecular Function	IPI (7073684)
GO:0005161	platelet-derived growth factor receptor binding	Molecular Function	IPI (2536956)
GO:0005161	platelet-derived growth factor receptor binding	Molecular Function	IDA (2439522)
GO:0005161	platelet-derived growth factor receptor binding	Molecular Function	IDA (2836953)
GO:0001775	cell activation	Biological Process	TAS (10508235)
GO:0045740	positive regulation of DNA replication	Biological Process	IDA (2439522\|2836953\|10806482)
GO:0048008	platelet-derived growth factor receptor signaling pathway	Biological Process	IDA (2439522\|2536956\|2836953)
GO:0048146	positive regulation of fibroblast proliferation	Biological Process	IDA (2439522\|10806482)
GO:0042060	wound healing	Biological Process	TAS (10508235)
GO:0032956	regulation of actin cytoskeleton organization and biogenesis	Biological Process	TAS (10508235)
GO:0030335	positive regulation of cell migration	Biological Process	IDA (17470632)
GO:0014910	regulation of smooth muscle cell migration	Biological Process	IDA (9409235)
GO:0010544	negative regulation of platelet activation	Biological Process	IDA (2538439)
GO:0010512	negative regulation of phosphatidylinositol biosynthetic process	Biological Process	IDA (2538439)
GO:0009790	embryonic development	Biological Process	TAS (10508235)
GO:0008283	cell proliferation	Biological Process	IEA
GO:0007267	cell-cell signaling	Biological Process	TAS (2842868)
GO:0050919	negative chemotaxis	Biological Process	IDA (9409235)