ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pdgfb

Full Name:

platelet derived growth factor, B polypeptide

Alias:

PDGF-B|Sis

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 E|15 46.8 cM

Physical Location:

79826303-79845237 on NC_000081.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5155 Symbol (Name): PDGFB (platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog))

Ortholog Status:

The human GeneID 5155 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore5	Alcohol-induced Loss of Righting Reflex	15		18.8-61.7 (cM)	4		Significant	PARC
Aaq1/Etacc	Alcohol Acceptance	15	30	15-48 (cM)	3.8		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011057.3	NP_035187.2	NC_000081.5 range: 79826303..79845237, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0008083	growth factor activity	Molecular Function	IEA
GO:0001938	positive regulation of endothelial cell proliferation	Biological Process	IGI (16644864)
GO:0030336	negative regulation of cell migration	Biological Process	IGI (16644864)
GO:0030036	actin cytoskeleton organization and biogenesis	Biological Process	IDA (12176888)
GO:0030031	cell projection biogenesis	Biological Process	IDA (12176888)
GO:0008283	cell proliferation	Biological Process	IEA
GO:0006929	substrate-bound cell migration	Biological Process	IDA (15183724)
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Biological Process	IDA (11940581)