ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

5155

Symbol:

PDGFB

Full Name:

platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

Alias:

FLJ12858|PDGF2|SIS|SSV|c-sis

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

22q12.3-q13.1|22q13.1

Physical Location:

37949664-37970935 on NC_000022.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 18591 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

PDGFB

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002608.1	NP_002599.1	NC_000022.9 range: 37949664..37970935, complement
NM_033016.1	NP_148937.1	NC_000022.9 range: 37949664..37970935, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0031089	platelet dense granule lumen	Cellular Component	EXP (287022)
GO:0009986	cell surface	Cellular Component	IDA (291037\|2836953\|9685360)
GO:0005576	extracellular region	Cellular Component	NAS (1661670)
GO:0005576	extracellular region	Cellular Component	EXP (287022)
GO:0042803	protein homodimerization activity	Molecular Function	IDA (2836953)
GO:0005161	platelet-derived growth factor receptor binding	Molecular Function	NAS (1661670)
GO:0046982	protein heterodimerization activity	Molecular Function	IPI (7073684)
GO:0005515	protein binding	Molecular Function	IPI (17981115)
GO:0048407	platelet-derived growth factor binding	Molecular Function	IPI (7073684)
GO:0008083	growth factor activity	Molecular Function	IEA
GO:0043498	cell surface binding	Molecular Function	IDA (291037\|2538439\|2836953)
GO:0048008	platelet-derived growth factor receptor signaling pathway	Biological Process	IDA (2439522\|2536956\|2836953)
GO:0048146	positive regulation of fibroblast proliferation	Biological Process	IDA (2439522)
GO:0045740	positive regulation of DNA replication	Biological Process	IDA (2439522\|2836953)
GO:0043536	positive regulation of blood vessel endothelial cell migration	Biological Process	IDA (9685360)
GO:0043406	positive regulation of MAP kinase activity	Biological Process	IDA (9685360)
GO:0001938	positive regulation of endothelial cell proliferation	Biological Process	IDA (9685360)
GO:0014911	positive regulation of smooth muscle cell migration	Biological Process	IDA (9409235)
GO:0010544	negative regulation of platelet activation	Biological Process	IDA (2538439)
GO:0010512	negative regulation of phosphatidylinositol biosynthetic process	Biological Process	IDA (2538439)
GO:0009611	response to wounding	Biological Process	NAS (1661670)
GO:0008283	cell proliferation	Biological Process	IEA
GO:0050921	positive regulation of chemotaxis	Biological Process	IDA (9409235)