ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pdpk1

Full Name:

3-phosphoinositide dependent protein kinase-1

Alias:

Pdk1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

17 A3.3

Physical Location:

24210646-24278555 on NC_000083.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5170 Symbol (Name): PDPK1 (3-phosphoinositide dependent protein kinase-1)

Ortholog Status:

The human GeneID 5170 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pdpk1
Original ID2:		AW122388

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016023	cytoplasmic membrane-bounded vesicle	Cellular Component	IDA (12783890)
GO:0016020	membrane	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IDA (12783890)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004676	3-phosphoinositide-dependent protein kinase activity	Molecular Function	IDA (10075713)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0006972	hyperosmotic response	Biological Process	IDA (12783890)
GO:0007165	signal transduction	Biological Process	TAS (10075713)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA