ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Penk1

Full Name:

preproenkephalin 1

Alias:

AI326464|ENK|PPA|Penk

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 A1|4 0.8 cM

Physical Location:

4060682-4065591 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5179 Symbol (Name): PENK (proenkephalin)

Ortholog Status:

The human GeneID 5179 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Penk1
Original ID2:		M55181

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001002927.2	NP_001002927.1	NC_000070.5 range: 4060682..4065591, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0001515	opioid peptide activity	Molecular Function	IEA
GO:0001662	behavioral fear response	Biological Process	IMP (11172058)
GO:0007218	neuropeptide signaling pathway	Biological Process	IEA
GO:0007610	behavior	Biological Process	IMP (8849726)
GO:0019233	sensory perception of pain	Biological Process	IMP (8849726)