ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Prkce

Full Name:

protein kinase C, epsilon

Alias:

5830406C15Rik|PKC[e]|PKCepsilon|Pkce|R75156

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

17 E4

Physical Location:

86567929-87054037 on NC_000083.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5581 Symbol (Name): PRKCE (protein kinase C, epsilon)

Ortholog Status:

The human GeneID 5581 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Prkce

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011104.1	NP_035234.1	NC_000083.5 range: 86567929..87054037

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (14613966)
GO:0005737	cytoplasm	Cellular Component	IDA (14613966)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0019992	diacylglycerol binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004699	calcium-independent protein kinase C activity	Molecular Function	IDA (10879655)
GO:0004697	protein kinase C activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0007635	chemosensory behavior	Biological Process	TAS (11606660)
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (12551921)
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Biological Process	IMP (11940581)