ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PRKCE

Full Name:

protein kinase C, epsilon

Alias:

MGC125656|MGC125657|PKCE|nPKC-epsilon

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2p21

Physical Location:

45732546-46268632 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 18754 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

PRKCE

Dataset Information

Name:		18477577
Method:		Addiction array gene list
Publication:		Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:		To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005400.2	NP_005391.1	NC_000002.10 range: 45732546..46268632

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005624	membrane fraction	Cellular Component	TAS (7935319)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0019992	diacylglycerol binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	TAS (1382605\|10438519)
GO:0004697	protein kinase C activity	Molecular Function	TAS (1382605)
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006917	induction of apoptosis	Biological Process	TAS (10438519)
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (1382605)