ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Prkcz

Full Name:

protein kinase C, zeta

Alias:

AI098070|C80388|Pkcz|R74924|zetaPKC

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 E2|4 83.0 cM

Physical Location:

154634228-154735499 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5590 Symbol (Name): PRKCZ (protein kinase C, zeta)

Ortholog Status:

The human GeneID 5590 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Prkcz

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap3q	Alcohol Preference Drinking	4	75	65-ter (cM)	4.6		Significant	PARC

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005923	tight junction	Cellular Component	IDA (15950600)
GO:0005737	cytoplasm	Cellular Component	IDA (12871585\|14730360)
GO:0005938	cell cortex	Cellular Component	IDA (15950600)
GO:0005768	endosome	Cellular Component	IEA
GO:0045179	apical cortex	Cellular Component	IDA (15950600)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0019992	diacylglycerol binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IDA (14730360)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004697	protein kinase C activity	Molecular Function	IEA
GO:0004700	atypical protein kinase C activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15102471)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (14730360)
GO:0000226	microtubule cytoskeleton organization and biogenesis	Biological Process	IMP (15882626)