ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PRKCZ

Full Name:

protein kinase C, zeta

Alias:

PKC-ZETA|PKC2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1p36.33-p36.2

Physical Location:

1971768-2106693 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 18762 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Z15108
Fold Change:		1.4, 1.8
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	TAS (7925449)
GO:0005624	membrane fraction	Cellular Component	TAS (7925449)
GO:0005737	cytoplasm	Cellular Component	TAS (7925449)
GO:0005768	endosome	Cellular Component	IEA
GO:0019992	diacylglycerol binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (11755531\|12893243)
GO:0004700	atypical protein kinase C activity	Molecular Function	TAS (8224878)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (10477520)
GO:0006916	anti-apoptosis	Biological Process	TAS (10770953)
GO:0007242	intracellular signaling cascade	Biological Process	IEA