ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Plp1

Full Name:

proteolipid protein (myelin) 1

Alias:

DM20|Plp|jimpy|jp|msd|rsh

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

X F1-F2|X 56.0 cM

Physical Location:

133357374-133372281 on NC_000086.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5354 Symbol (Name): PLP1 (proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated))

Ortholog Status:

The human GeneID 5354 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Plp
Original ID2:		M16472

Gene Information

Original ID1:		Plp
Original ID2:		M37335

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011123.2	NP_035253.1	NC_000086.6 range: 133357374..133372281

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0043209	myelin sheath	Cellular Component	IDA (1694232)
GO:0016020	membrane	Cellular Component	IEA
GO:0005198	structural molecule activity	Molecular Function	RCA (12466851)
GO:0005515	protein binding	Molecular Function	IPI (15284227)
GO:0008366	axon ensheathment	Biological Process	RCA (12466851)
GO:0008366	axon ensheathment	Biological Process	IMP (14169723)
GO:0007268	synaptic transmission	Biological Process	RCA (12466851)
GO:0022010	myelination in the central nervous system	Biological Process	IMP (1694232)
GO:0042552	myelination	Biological Process	IMP (1150661)
GO:0042552	myelination	Biological Process	TAS (12091477)
GO:0042759	long-chain fatty acid biosynthetic process	Biological Process	IMP (1150661)
GO:0048469	cell maturation	Biological Process	IMP (11746780)