ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

18854

Symbol:

Pml

Full Name:

promyelocytic leukemia

Alias:

1200009E24Rik|AI661194|Trim19

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 B|9 32.0 cM

Physical Location:

58066348-58097592 on NC_000075.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5371 Symbol (Name): PML (promyelocytic leukemia)

Ortholog Status:

The human GeneID 5371 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap5q	Alcohol Preference Drinking	9	25	10-35 (cM)	4.8		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008884.5	NP_032910.3	NC_000075.5 range: 58066348..58097592, complement
NM_178087.4	NP_835188.2	NC_000075.5 range: 58066348..58097592, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016605	PML body	Cellular Component	IMP (10779416)
GO:0016363	nuclear matrix	Cellular Component	IDA (15252119)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (10716735)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046332	SMAD binding	Molecular Function	IPI (15356634)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0030528	transcription regulator activity	Molecular Function	IDA (9845074)
GO:0005515	protein binding	Molecular Function	IPI (12529400\|15356634\|15925207\|16915281)
GO:0003713	transcription coactivator activity	Molecular Function	TAS (15626733)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0016525	negative regulation of angiogenesis	Biological Process	IMP (16915281)
GO:0010332	response to gamma radiation	Biological Process	IMP (9806545\|11025664)
GO:0030099	myeloid cell differentiation	Biological Process	IMP (9488655)
GO:0030578	PML body organization and biogenesis	Biological Process	IDA (12529400)
GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	Biological Process	IMP (15626733)
GO:0045343	regulation of MHC class I biosynthetic process	Biological Process	IDA (9845074)
GO:0048384	retinoic acid receptor signaling pathway	Biological Process	IMP (9488655)
GO:0009411	response to UV	Biological Process	IMP (15626733)
GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	Biological Process	IMP (9806545\|15626733)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006917	induction of apoptosis	Biological Process	IMP (9806545\|14992722)
GO:0006919	caspase activation	Biological Process	IMP (9806545)
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Biological Process	IMP (15626733)
GO:0007050	cell cycle arrest	Biological Process	IMP (10910364)
GO:0007179	transforming growth factor beta receptor signaling pathway	Biological Process	IMP (15356634)
GO:0007182	common-partner SMAD protein phosphorylation	Biological Process	IMP (15356634)
GO:0007184	SMAD protein nuclear translocation	Biological Process	IMP (15356634)
GO:0007569	cell aging	Biological Process	IMP (10910364)
GO:0001666	response to hypoxia	Biological Process	IMP (16915281)
GO:0008285	negative regulation of cell proliferation	Biological Process	IMP (9488655)
GO:0051457	maintenance of protein localization in nucleus	Biological Process	ISS (17332504)