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Gene Information
Gene ID:5371
Symbol:PML
Full Name:promyelocytic leukemia
Alias:MYL|PP8675|RNF71|TRIM19
Organism:Homo sapiens (Human)
Chromosome:15
Genetic Location:15q22
Physical Location:72074066-72127212 on NC_000015.8
Gene Type:protein-coding
Orthologs:This gene has Mouse: 18854 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:W38850
Fold Change:1.59
P Value:0.01
Tissue:Prefrontal cortex
Dataset Information
Name:15816859
Method:Microarray
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Gene Information
Original ID1:PML
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002675.3NP_002666.1NC_000015.8 range: 72074066..72127212
NM_033238.2NP_150241.2NC_000015.8 range: 72074066..72127212
NM_033239.2NP_150242.1NC_000015.8 range: 72074066..72127212
NM_033240.2NP_150243.2NC_000015.8 range: 72074066..72127212
NM_033244.3NP_150247.2NC_000015.8 range: 72074066..72127212
NM_033246.2NP_150249.1NC_000015.8 range: 72074066..72127212
NM_033247.2NP_150250.2NC_000015.8 range: 72074066..72127212
NM_033249.2NP_150252.1NC_000015.8 range: 72074066..72127212
NM_033250.2NP_150253.2NC_000015.8 range: 72074066..72127212
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIDA (16778193)
GO:0005730nucleolusCellular ComponentIDA (15195100)
GO:0005654nucleoplasmCellular ComponentIDA (12915590)
GO:0005634nucleusCellular ComponentIEA
GO:0005626insoluble fractionCellular ComponentIDA (12915590)
GO:0005622intracellularCellular ComponentIEA
GO:0016605PML bodyCellular ComponentIDA (10910364)
GO:0016605PML bodyCellular ComponentIDA (9448006|17081985)
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionNAS (1652369)
GO:0032183SUMO bindingMolecular FunctionIPI (17081985)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0016564transcription repressor activityMolecular FunctionIDA (11432836)
GO:0005515protein bindingMolecular FunctionIPI (9294197|9671405|11259576|11432836|12915590|14976184|15626733|16915281)
GO:0005515protein bindingMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionIEA
GO:0003676nucleic acid bindingMolecular FunctionNAS (1652369)
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisBiological ProcessISS
GO:0030578PML body organization and biogenesisBiological ProcessIMP (17081985)
GO:0030308negative regulation of cell growthBiological ProcessIDA (9448006)
GO:0001666response to hypoxiaBiological ProcessIDA (16915281)
GO:0016525negative regulation of angiogenesisBiological ProcessIMP (16915281)
GO:0016481negative regulation of transcriptionBiological ProcessIDA (9448006)
GO:0010212response to ionizing radiationBiological ProcessIDA (12773567)
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestBiological ProcessISS
GO:0006917induction of apoptosisBiological ProcessIMP (16912307)
GO:0006461protein complex assemblyBiological ProcessIDA (12915590)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006281DNA repairBiological ProcessNAS (12773567)
GO:0051457maintenance of protein localization in nucleusBiological ProcessIDA (17332504)
Other Database Cross Links
NCBI Entrez Gene:5371
HGNC:9113
Ensembl:ENSG00000140464
MIM:102578
HPRD:00023
HuGE Navigator:5371
dbSNP:PML
GeneCard:PML
AceView:PML