ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

18999

Symbol:

Pou5f1

Full Name:

POU domain, class 5, transcription factor 1

Alias:

Oct-3|Oct-3/4|Oct-4|Oct3|Oct3/4|Oct4|Otf-3|Otf-4|Otf3|Otf3-rs7|Otf3g|Otf4

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

17 B1|17 19.23 cM

Physical Location:

35642983-35647721 on NC_000083.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5460 Symbol (Name): POU5F1 (POU class 5 homeobox 1)

Ortholog Status:

The human GeneID 5460 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pou5f1
Original ID2:		AV214633

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013633.2	NP_038661.2	NC_000083.5 range: 35642983..35647721

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (7958450\|7969117\|9507072\|15525667\|16611995)
GO:0005737	cytoplasm	Cellular Component	IDA (7958450)
GO:0005667	transcription factor complex	Cellular Component	IDA (7969117)
GO:0005634	nucleus	Cellular Component	IC (12665572)
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (1690859\|7945330\|7969117\|8960364\|9649510\|16518401)
GO:0005515	protein binding	Molecular Function	IPI (15917470\|18191611)
GO:0003700	transcription factor activity	Molecular Function	IDA (1967980\|1972777\|2357966\|12665572)
GO:0003677	DNA binding	Molecular Function	IGI (15863505)
GO:0003677	DNA binding	Molecular Function	IDA (1967980\|12665572)
GO:0045165	cell fate commitment	Biological Process	IMP (9814708)
GO:0045449	regulation of transcription	Biological Process	IEA
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA (1967980)
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA (1967980)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (7590241\|9649510\|15863505)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (1972777\|9649510)
GO:0001710	mesodermal cell fate commitment	Biological Process	IDA (10742100)
GO:0030718	germ-line stem cell maintenance	Biological Process	IMP (15486564)
GO:0019827	stem cell maintenance	Biological Process	IMP (9814708\|16767105)
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	IDA (1967980)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IDA (12665572)
GO:0006350	transcription	Biological Process	IEA
GO:0001712	ectodermal cell fate commitment	Biological Process	IDA (10742100)
GO:0001711	endodermal cell fate commitment	Biological Process	IDA (10742100)
GO:0045955	negative regulation of calcium ion-dependent exocytosis	Biological Process	IDA (2357966)