ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NR0B1

Full Name:

nuclear receptor subfamily 0, group B, member 1

Alias:

AHC|AHCH|AHX|DAX-1|DAX1|DSS|GTD|HHG|NROB1

Organism:

Homo sapiens (Human)

Chromosome:

X

Genetic Location:

Xp21.3-p21.2

Physical Location:

30232505-30237412 on NC_000023.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.268490
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000475.4	NP_000466.2	NC_000023.9 range: 30232505..30237412, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (16709599)
GO:0042788	polysomal ribosome	Cellular Component	IDA (10848616)
GO:0005624	membrane fraction	Cellular Component	IDA (10848616)
GO:0005737	cytoplasm	Cellular Component	IDA (16709599)
GO:0032448	DNA hairpin binding	Molecular Function	IDA (9384387)
GO:0035258	steroid hormone receptor binding	Molecular Function	IPI (11875111)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0042803	protein homodimerization activity	Molecular Function	IPI (16709599)
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (9384387)
GO:0019904	protein domain specific binding	Molecular Function	IPI (15100213)
GO:0017163	negative regulator of basal transcription activity	Molecular Function	IDA (9384387)
GO:0003706	ligand-regulated transcription factor activity	Molecular Function	IDA (7990953)
GO:0003707	steroid hormone receptor activity	Molecular Function	IEA
GO:0003723	RNA binding	Molecular Function	IDA (10848616)
GO:0008584	male gonad development	Biological Process	IMP (7990958)
GO:0006694	steroid biosynthetic process	Biological Process	IDA (9384387)
GO:0033144	negative regulation of steroid hormone receptor signaling pathway	Biological Process	IDA (11875111)
GO:0008104	protein localization	Biological Process	IDA (11875111)
GO:0030325	adrenal gland development	Biological Process	IMP (7990953)
GO:0021983	pituitary gland development	Biological Process	NAS (15464421)
GO:0021854	hypothalamus development	Biological Process	NAS (15464421)
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA (9384387)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000169297

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: