ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ppargc1a

Full Name:

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 C1

Physical Location:

51848891-51945099 on NC_000071.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10891 Symbol (Name): PPARGC1A (peroxisome proliferator-activated receptor gamma, coactivator 1 alpha)

Ortholog Status:

The human GeneID 10891 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ppargc1a
Original ID2:		AF049330

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008904.1	NP_032930.1	NC_000071.5 range: 51848891..51945099, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IC (15681609)
GO:0016563	transcription activator activity	Molecular Function	IDA (15681609)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17050673)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0003723	RNA binding	Molecular Function	IEA
GO:0003713	transcription coactivator activity	Molecular Function	IMP (16271724)
GO:0003677	DNA binding	Molecular Function	IDA (15681609)
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0022904	respiratory electron transport chain	Biological Process	IDA (14744933)
GO:0045941	positive regulation of transcription	Biological Process	IDA (14744933\|15681609)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (15199055)