ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Prkar1b

Full Name:

protein kinase, cAMP dependent regulatory, type I beta

Alias:

AI385716|RIbeta

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 G2|5 82.0 cM

Physical Location:

139493259-139605644 on NC_000071.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5575 Symbol (Name): PRKAR1B (protein kinase, cAMP-dependent, regulatory, type I, beta)

Ortholog Status:

The human GeneID 5575 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Prkar1b
Original ID2:		AW125016

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008923.2	NP_032949.2	NC_000071.5 range: 139493259..139605644, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	TAS (1448119)
GO:0005952	cAMP-dependent protein kinase complex	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0008603	cAMP-dependent protein kinase regulator activity	Molecular Function	ISS (3375237\|8032683)
GO:0030552	cAMP binding	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0008283	cell proliferation	Biological Process	TAS (7775586)
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (7775586)
GO:0009887	organ morphogenesis	Biological Process	TAS (7775586)
GO:0001932	regulation of protein amino acid phosphorylation	Biological Process	IEA
GO:0007611	learning and/or memory	Biological Process	IMP (7568030)