ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

191575

Symbol:

Nme1

Full Name:

expressed in non-metastatic cells 1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q26

Physical Location:

82591704-82601074 on NC_005109.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4830 Symbol (Name): NME1 (non-metastatic cells 1, protein (NM23A) expressed in)

Ortholog Status:

The human GeneID 4830 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		191575
Fold Change:		1.385
P Value:		0.0155
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_138548.1	NP_612557.1	NC_005109.2 range: 82591704..82601074, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005625	soluble fraction	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IEA
GO:0005792	microsome	Cellular Component	ISS
GO:0005813	centrosome	Cellular Component	IDA (11139339)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0043015	gamma-tubulin binding	Molecular Function	IDA (11139339)
GO:0005525	GTP binding	Molecular Function	ISS
GO:0005524	ATP binding	Molecular Function	ISS
GO:0005524	ATP binding	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	ISS
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0004550	nucleoside diphosphate kinase activity	Molecular Function	IDA (11139339)
GO:0004550	nucleoside diphosphate kinase activity	Molecular Function	IEA
GO:0004550	nucleoside diphosphate kinase activity	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IPI
GO:0005515	protein binding	Molecular Function	ISS
GO:0004536	deoxyribonuclease activity	Molecular Function	ISS
GO:0043388	positive regulation of DNA binding	Biological Process	ISS
GO:0030879	mammary gland development	Biological Process	ISS
GO:0009117	nucleotide metabolic process	Biological Process	IEA
GO:0007595	lactation	Biological Process	ISS
GO:0006241	CTP biosynthetic process	Biological Process	IEA
GO:0006228	UTP biosynthetic process	Biological Process	IEA
GO:0006183	GTP biosynthetic process	Biological Process	IEA
GO:0006165	nucleoside diphosphate phosphorylation	Biological Process	IDA (11139339)
GO:0050679	positive regulation of epithelial cell proliferation	Biological Process	ISS