ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Psmb6

Full Name:

proteasome (prosome, macropain) subunit, beta type 6

Alias:

Lmp19|Mpnd

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B3|11 39.0 cM

Physical Location:

70338901-70341150 on NC_000077.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5694 Symbol (Name): PSMB6 (proteasome (prosome, macropain) subunit, beta type, 6)

Ortholog Status:

The human GeneID 5694 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Psmb6

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

Gene Information

Dataset Information

Name:		16783646
Method:		Microarray and QTL
Tissue:		Whole brain
Phenotype:		Alcohol preference, acute functional tolerance
Publication:		Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
Summary:		Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore4	Alcohol-induced Loss of Righting Reflex	11		36-42 (cM)	6.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008946.3	NP_032972.2	NC_000077.5 range: 70338901..70341150

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0043234	protein complex	Cellular Component	IEA
GO:0005839	proteasome core complex	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0004298	threonine endopeptidase activity	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0004175	endopeptidase activity	Molecular Function	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA