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Gene Information
Gene ID:19175
Full Name:proteasome (prosome, macropain) subunit, beta type 6
Organism:Mus musculus (Mouse)
Genetic Location:11 B3|11 39.0 cM
Physical Location:70338901-70341150 on NC_000077.5
Gene Type:protein-coding
Human Ortholog:GeneID: 5694    Symbol (Name): PSMB6 (proteasome (prosome, macropain) subunit, beta type, 6)
Ortholog Status:The human GeneID 5694 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Psmb6
Dataset Information
Tissue:Whole brain
Phenotype:Alcohol preference
Publication:Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (|d|) and lowest Q values.
Gene Information
Original ID1:Psmb6
Fold Change:11.76
P Value:0
Note:acute functional tolerance
Dataset Information
Method:Microarray and QTL
Tissue:Whole brain
Phenotype:Alcohol preference, acute functional tolerance
Publication:Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
Summary:Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Lore4Alcohol-induced Loss of Righting Reflex11 36-42 (cM)6.5 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_008946.3NP_032972.2NC_000077.5 range: 70338901..70341150
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043234protein complexCellular ComponentIEA
GO:0005839proteasome core complexCellular ComponentIEA
GO:0005829cytosolCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0004298threonine endopeptidase activityMolecular FunctionIEA
GO:0008233peptidase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0004175endopeptidase activityMolecular FunctionIEA
GO:0006511ubiquitin-dependent protein catabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:19175