ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PSMB6

Full Name:

proteasome (prosome, macropain) subunit, beta type, 6

Alias:

DELTA|LMPY|MGC5169|Y

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17p13

Physical Location:

4646414-4648747 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 19175 Fly: 46058 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002798.1	NP_002789.1	NC_000017.9 range: 4646414..4648747

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	IEA
GO:0005839	proteasome core complex	Cellular Component	NAS
GO:0004298	threonine endopeptidase activity	Molecular Function	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	NAS
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	EXP (11285280)
GO:0051436	negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (15029244)
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (12791267)