Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:5694
Symbol:PSMB6
Full Name:proteasome (prosome, macropain) subunit, beta type, 6
Alias:DELTA|LMPY|MGC5169|Y
Organism:Homo sapiens (Human)
Chromosome:17
Genetic Location:17p13
Physical Location:4646414-4648747 on NC_000017.9
Gene Type:protein-coding
Orthologs:This gene has Mouse: 19175 Fly: 46058 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:BQ052212
Fold Change:0.67
P Value:9.00E-04
Tissue:Nucleus accumbens
Dataset Information
Name:15816859
Method:Microarray
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002798.1NP_002789.1NC_000017.9 range: 4646414..4648747
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0005829cytosolCellular ComponentIEA
GO:0005839proteasome core complexCellular ComponentNAS
GO:0004298threonine endopeptidase activityMolecular FunctionIEA
GO:0006511ubiquitin-dependent protein catabolic processBiological ProcessNAS
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processBiological ProcessEXP (11285280)
GO:0051436negative regulation of ubiquitin-protein ligase activity during mitotic cell cycleBiological ProcessEXP (15029244)
GO:0051437positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleBiological ProcessEXP (12791267)
Other Database Cross Links
NCBI Entrez Gene:5694
HGNC:9543
Ensembl:ENSG00000142507
MIM:600307
HPRD:02630
HuGE Navigator:5694
dbSNP:PSMB6
GeneCard:PSMB6
AceView:PSMB6