ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ptgs2

Full Name:

prostaglandin-endoperoxide synthase 2

Alias:

COX2|Cox-2|PGHS-2|PHS-2|Pghs2|TIS10

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H1|1 76.2 cM

Physical Location:

151947253-151955146 on NC_000067.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5743 Symbol (Name): PTGS2 (prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase))

Ortholog Status:

The human GeneID 5743 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011198.3	NP_035328.2	NC_000067.5 range: 151947253..151955146

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005792	microsome	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005634	nucleus	Cellular Component	IDA (12021206)
GO:0005737	cytoplasm	Cellular Component	IDA (12021206)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0020037	heme binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0004666	prostaglandin-endoperoxide synthase activity	Molecular Function	IEA
GO:0004601	peroxidase activity	Molecular Function	IEA
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Molecular Function	IEA
GO:0042640	anagen	Biological Process	IMP (15713628)
GO:0042127	regulation of cell proliferation	Biological Process	IGI (8945508)
GO:0030216	keratinocyte differentiation	Biological Process	NAS (12067981)
GO:0008610	lipid biosynthetic process	Biological Process	IEA
GO:0008217	regulation of blood pressure	Biological Process	IMP (12093889)
GO:0006979	response to oxidative stress	Biological Process	IEA
GO:0006633	fatty acid biosynthetic process	Biological Process	IEA
GO:0001516	prostaglandin biosynthetic process	Biological Process	IEA