ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PTGS2

Full Name:

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Alias:

COX-2|COX2|GRIPGHS|PGG/HS|PGHS-2|PHS-2|hCox-2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q25.2-q25.3

Physical Location:

184907591-184916178 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 19225 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

PTGS2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000963.1	NP_000954.1	NC_000001.9 range: 184907591..184916178, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005792	microsome	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IDA (14511332)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005788	endoplasmic reticulum lumen	Cellular Component	EXP (4514999)
GO:0016020	membrane	Cellular Component	IEA
GO:0020037	heme binding	Molecular Function	IEA
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Molecular Function	IEA
GO:0009053	electron donor activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0004601	peroxidase activity	Molecular Function	EXP (4514999)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0004666	prostaglandin-endoperoxide synthase activity	Molecular Function	NAS (14511332)
GO:0004666	prostaglandin-endoperoxide synthase activity	Molecular Function	IEA
GO:0004601	peroxidase activity	Molecular Function	NAS (14511332)
GO:0004601	peroxidase activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0019371	cyclooxygenase pathway	Biological Process	NAS (14511332)
GO:0008217	regulation of blood pressure	Biological Process	ISS
GO:0006979	response to oxidative stress	Biological Process	IEA
GO:0006928	cell motility	Biological Process	TAS (9630216)
GO:0006633	fatty acid biosynthetic process	Biological Process	IEA
GO:0050727	regulation of inflammatory response	Biological Process	NAS (14511332)