ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ppap2b

Full Name:

phosphatidic acid phosphatase type 2B

Alias:

Dri42

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

5q34

Physical Location:

126121415-126197098 on NC_005104.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8613 Symbol (Name): PPAP2B (phosphatidic acid phosphatase type 2B)

Ortholog Status:

The human GeneID 8613 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ppap2b
Fold Change:		1.15
P Value:		0.002
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_138905.2	NP_620260.2	NC_005104.2 range: 126121415..126197098

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IDA (8939937)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008195	phosphatidate phosphatase activity	Molecular Function	IEA
GO:0042577	lipid phosphatase activity	Molecular Function	IEA
GO:0042577	lipid phosphatase activity	Molecular Function	ISS
GO:0030111	regulation of Wnt receptor signaling pathway	Biological Process	ISS
GO:0030111	regulation of Wnt receptor signaling pathway	Biological Process	IEA
GO:0006644	phospholipid metabolic process	Biological Process	ISS
GO:0006644	phospholipid metabolic process	Biological Process	IEA
GO:0001702	gastrulation with mouth forming second	Biological Process	ISS
GO:0001568	blood vessel development	Biological Process	ISS
GO:0001568	blood vessel development	Biological Process	IEA