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Gene Information
Gene ID:19243
Symbol:Ptp4a1
Full Name:protein tyrosine phosphatase 4a1
Alias:AA415290|AU019864|C130021B01|MGC102117|MGC25304|Prl-1
Organism:Mus musculus (Mouse)
Chromosome:1
Genetic Location:1 B
Physical Location:30997147-31006599 on NC_000067.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 7803    Symbol (Name): PTP4A1 (protein tyrosine phosphatase type IVA, member 1)
Ortholog Status:The human GeneID 7803 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ptp4a1
Original ID2:U84411
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Information
Original ID1:Ptp4a1
Dataset Information
Name:16618939
Method:Microarray
Tissue:Whole brain
Phenotype:Alcohol preference
Publication:Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (|d|) and lowest Q values.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_011200.2NP_035330.1NC_000067.5 range: 30997147..31006599, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentTAS (12782572)
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005768endosomeCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0004727prenylated protein tyrosine phosphatase activityMolecular FunctionTAS (12782572)
GO:0004725protein tyrosine phosphatase activityMolecular FunctionIEA
GO:0016791phosphoric monoester hydrolase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0004721phosphoprotein phosphatase activityMolecular FunctionIEA
GO:0016311dephosphorylationBiological ProcessIEA
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0007049cell cycleBiological ProcessIEA
GO:0006470protein amino acid dephosphorylationBiological ProcessIEA
GO:0030335positive regulation of cell migrationBiological ProcessIDA (12782572)
Other Database Cross Links
NCBI Entrez Gene:19243
MGI:
Ensembl:ENSMUSG00000026064
dbSNP:Ptp4a1
AceView:Ptp4a1