ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Rab7

Full Name:

RAB7, member RAS oncogene family

Alias:

MGC102153

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 D1|6 38.5 cM

Physical Location:

87949116-87995213 on NC_000072.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7879 Symbol (Name): RAB7A (RAB7A, member RAS oncogene family)

Ortholog Status:

The human GeneID 7879 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rab7
Original ID2:		Y13361

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009005.2	NP_033031.2	NC_000072.5 range: 87949116..87995213, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IDA (11042173)
GO:0005770	late endosome	Cellular Component	ISS (15078902)
GO:0005770	late endosome	Cellular Component	IDA (11172003\|15588329)
GO:0005768	endosome	Cellular Component	IEA
GO:0005764	lysosome	Cellular Component	ISS (15078902)
GO:0005525	GTP binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006886	intracellular protein transport	Biological Process	TAS (11042173)
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA
GO:0015031	protein transport	Biological Process	IEA