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Gene Information
Gene ID:19353
Full Name:RAS-related C3 botulinum substrate 1
Organism:Mus musculus (Mouse)
Genetic Location:5 G2|5 82.0 cM
Physical Location:144266348-144288860 on NC_000071.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5879    Symbol (Name): RAC1 (ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1))
Ortholog Status:The human GeneID 5879 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rac1
Fold Change:1.34
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009007.2NP_033033.1NC_000071.5 range: 144266348..144288860, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0042995cell projectionCellular ComponentIDA (15728722)
GO:0030027lamellipodiumCellular ComponentIDA (12783890|14657280)
GO:0019897extrinsic to plasma membraneCellular ComponentIDA (14516655)
GO:0005622intracellularCellular ComponentIEA
GO:0005624membrane fractionCellular ComponentIDA (14657280)
GO:0005737cytoplasmCellular ComponentIDA (12213441)
GO:0016023cytoplasmic membrane-bounded vesicleCellular ComponentIDA (12783890|14516655)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0003924GTPase activityMolecular FunctionIDA (10699171|12525493|15249579)
GO:0005515protein bindingMolecular FunctionIPI (8543060|14573547|14580336)
GO:0005525GTP bindingMolecular FunctionIDA (12783890|14580336|15728191)
GO:0007010cytoskeleton organization and biogenesisBiological ProcessIDA (14657280)
GO:0030838positive regulation of actin filament polymerizationBiological ProcessIDA (12853475)
GO:0030334regulation of cell migrationBiological ProcessIMP (17409253)
GO:0030032lamellipodium biogenesisBiological ProcessTAS (12351724)
GO:0030032lamellipodium biogenesisBiological ProcessIDA (15728191)
GO:0021831embryonic olfactory bulb interneuron precursor migrationBiological ProcessIMP (17409253)
GO:0021799cerebral cortex radially oriented cell migrationBiological ProcessIMP (17409253)
GO:0016477cell migrationBiological ProcessIDA (15728191)
GO:0016358dendrite developmentBiological ProcessIDA (12213441)
GO:0006897endocytosisBiological ProcessIDA (12446704)
GO:0006972hyperosmotic responseBiological ProcessIDA (12783890)
GO:0007411axon guidanceBiological ProcessIMP (17409253)
GO:0007264small GTPase mediated signal transductionBiological ProcessIDA (12525493)
GO:0007155cell adhesionBiological ProcessIDA (14657280)
GO:0043552positive regulation of phosphoinositide 3-kinase activityBiological ProcessIMP (15728722)
Other Database Cross Links
NCBI Entrez Gene:19353